BDBM33953 dihydroxy benzoyl naphthyl hydrazone (DHBNH)

SMILES: COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1

InChI Key: InChIKey=TVOPERZEGKBKAY-RGVLZGJSSA-N

Data: 9 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 33953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase RNase H (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	8.0	37
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
HIV-1 Reverse Transcriptase RNase H (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	7.8	37
Rutgers University					Assay Description HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
HIV-1 Reverse Transcriptase RNase H Mutant (Y181C) (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
HIV-1 Reverse Transcriptase RNase H Mutant (Y188L) (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assay				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
					More data for this Ligand-Target Pair				3D Structure (crystal)
HIV-1 Reverse Transcriptase RNase H Mutant (L100I/K103N) (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
HIV-1 Reverse Transcriptase RNase H Mutant (D67N/K70R/T215F/K219Q) (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting method				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase RNase H Mutant (V106A/Y181C) (Human immunodeficiency virus type 1)	BDBM33953 (dihydroxy benzoyl naphthyl hydrazone (DHBNH)) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H16N2O4/c1-25-18-9-7-12-4-2-3-5-14(12)15(18)11-20-21-19(24)13-6-8-16(22)17(23)10-13/h2-11,22-23H,1H3,(H,21,24)/b20-11+	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair				3D Structure (crystal)