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BDBM33956 dihydroxy benzoyl naphthyl hydrazone (DHBNH) analogue, 3

SMILES: COc1ccc(cc1)C(=O)N\N=C\c1c(OC)ccc2ccccc12

InChI Key: InChIKey=FSSNWTAENDFNCF-FYJGNVAPSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 33956   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33956
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc(cc1)C(=O)N\N=C\c1c(OC)ccc2ccccc12
Show InChI InChI=1S/C20H18N2O3/c1-24-16-10-7-15(8-11-16)20(23)22-21-13-18-17-6-4-3-5-14(17)9-12-19(18)25-2/h3-13H,1-2H3,(H,22,23)/b21-13+
PDB
MMDB

B.MOAD
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.837



Rutgers University



Assay Description
HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33956
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc(cc1)C(=O)N\N=C\c1c(OC)ccc2ccccc12
Show InChI InChI=1S/C20H18N2O3/c1-24-16-10-7-15(8-11-16)20(23)22-21-13-18-17-6-4-3-5-14(17)9-12-19(18)25-2/h3-13H,1-2H3,(H,22,23)/b21-13+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+4n/an/an/an/a8.037



Rutgers University



Assay Description
To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair