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BDBM33958 dihydroxy benzoyl naphthyl hydrazone (DHBNH) analogue, 5

SMILES: COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=YHONUWNAKKJDIE-BUVRLJJBSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 33958   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33958
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-12-9-17(10-13-18)22(26)25-24-15-20-19-8-6-5-7-16(19)11-14-21(20)27-4/h5-15H,1-4H3,(H,25,26)/b24-15+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a7.837



Rutgers University



Assay Description
HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33958
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-12-9-17(10-13-18)22(26)25-24-15-20-19-8-6-5-7-16(19)11-14-21(20)27-4/h5-15H,1-4H3,(H,25,26)/b24-15+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/a8.037



Rutgers University



Assay Description
To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair