BDBM33960 dihydroxy benzoyl naphthyl hydrazone (DHBNH) analogue, 7

SMILES: COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=GMQLDADYHGGEBI-YZSQISJMSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 33960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase RNase H (Human immunodeficiency virus type 1)	BDBM33960 (dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H20N2O3/c1-29-24-16-13-18-7-5-6-10-22(18)23(24)17-26-27-25(28)19-11-14-21(15-12-19)30-20-8-3-2-4-9-20/h2-17H,1H3,(H,27,28)/b26-17+	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	8.0	37
Rutgers University					Assay Description To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM33960 (dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H20N2O3/c1-29-24-16-13-18-7-5-6-10-22(18)23(24)17-26-27-25(28)19-11-14-21(15-12-19)30-20-8-3-2-4-9-20/h2-17H,1H3,(H,27,28)/b26-17+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting method				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM33960 (dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H20N2O3/c1-29-24-16-13-18-7-5-6-10-22(18)23(24)17-26-27-25(28)19-11-14-21(15-12-19)30-20-8-3-2-4-9-20/h2-17H,1H3,(H,27,28)/b26-17+	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assay				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase RNase H (Human immunodeficiency virus type 1)	BDBM33960 (dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...) Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H20N2O3/c1-29-24-16-13-18-7-5-6-10-22(18)23(24)17-26-27-25(28)19-11-14-21(15-12-19)30-20-8-3-2-4-9-20/h2-17H,1H3,(H,27,28)/b26-17+	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.8	37
Rutgers University					Assay Description HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...				ACS Chem Biol 1: 702-12 (2006) Article DOI: 10.1021/cb600303y BindingDB Entry DOI: 10.7270/Q2FF3QQC
					More data for this Ligand-Target Pair