BindingDB PrimarySearch

BDBM33970 maleimide derivative, 12

SMILES: CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1

InChI Key: InChIKey=IDSZLHFEKAUIOL-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 33970
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCbeta-1 by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCdelta by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCepsilon by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCtheta by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	23
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCalpha by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair
Protein Kinase C, eta (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	25
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	25
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	23
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair
Protein kinase C, eta (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCeta by scintillation proximity assay				J Med Chem 54: 6028-39 (2011) Article DOI: 10.1021/jm200469u BindingDB Entry DOI: 10.7270/Q2K35VR1
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM33970 (maleimide derivative, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.4	23
Novartis					Assay Description Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...				J Med Chem 52: 6193-6 (2009) Article DOI: 10.1021/jm901108b BindingDB Entry DOI: 10.7270/Q25X278Q
Novartis					More data for this Ligand-Target Pair