BDBM339819 US9757364, Compound 13

SMILES: CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1

InChI Key: InChIKey=OVZKBAUSZIANJA-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 339819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM339819 (US9757364, Compound 13) Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C26H32N6O2/c1-6-31-17-20(16-29-31)19-11-25-24(28-15-19)7-8-26(30-25)32(10-9-27-18(2)3)21-12-22(33-4)14-23(13-21)34-5/h7-8,11-18,27H,6,9-10H2,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.29	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM339819 (US9757364, Compound 13) Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C26H32N6O2/c1-6-31-17-20(16-29-31)19-11-25-24(28-15-19)7-8-26(30-25)32(10-9-27-18(2)3)21-12-22(33-4)14-23(13-21)34-5/h7-8,11-18,27H,6,9-10H2,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM339819 (US9757364, Compound 13) Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C26H32N6O2/c1-6-31-17-20(16-29-31)19-11-25-24(28-15-19)7-8-26(30-25)32(10-9-27-18(2)3)21-12-22(33-4)14-23(13-21)34-5/h7-8,11-18,27H,6,9-10H2,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.2	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM339819 (US9757364, Compound 13) Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C26H32N6O2/c1-6-31-17-20(16-29-31)19-11-25-24(28-15-19)7-8-26(30-25)32(10-9-27-18(2)3)21-12-22(33-4)14-23(13-21)34-5/h7-8,11-18,27H,6,9-10H2,1-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM339819 (US9757364, Compound 13) Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)N(CCNC(C)C)c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C26H32N6O2/c1-6-31-17-20(16-29-31)19-11-25-24(28-15-19)7-8-26(30-25)32(10-9-27-18(2)3)21-12-22(33-4)14-23(13-21)34-5/h7-8,11-18,27H,6,9-10H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.55	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair