BindingDB logo
myBDB logout

null

SMILES: Fc1ccc2c(c[nH]c2c1)-c1ccc(OC2CCNCC2)nc1

InChI Key: InChIKey=BHLNCSQMPNPWHT-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339929   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))		BDBM339929
PNG
(6-fluoro-3-(6-(piperidin-4- yloxy)pyridin-3-yl)-1H...)
Show SMILES Fc1ccc2c(c[nH]c2c1)-c1ccc(OC2CCNCC2)nc1
Show InChI InChI=1S/C18H18FN3O/c19-13-2-3-15-16(11-21-17(15)9-13)12-1-4-18(22-10-12)23-14-5-7-20-8-6-14/h1-4,9-11,14,20-21H,5-8H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 560n/an/an/an/an/an/a



iTeos Therapeutics

US Patent


Assay Description
The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...

US Patent US9758505 (2017)


BindingDB Entry DOI: 10.7270/Q20V8FW9
More data for this
Ligand-Target Pair