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SMILES: Fc1ccc2c(c[nH]c2c1)-c1ccc(nc1)N1CCOCC1

InChI Key: InChIKey=WKOLPWOWLBJZGD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339941   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))		BDBM339941
PNG
(4-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)morphol...)
Show SMILES Fc1ccc2c(c[nH]c2c1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C17H16FN3O/c18-13-2-3-14-15(11-19-16(14)9-13)12-1-4-17(20-10-12)21-5-7-22-8-6-21/h1-4,9-11,19H,5-8H2
PDB

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US Patent
n/an/a 540n/an/an/an/an/an/a



iTeos Therapeutics

US Patent


Assay Description
The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...

US Patent US9758505 (2017)


BindingDB Entry DOI: 10.7270/Q20V8FW9
More data for this
Ligand-Target Pair