BindingDB logo
myBDB logout

null

SMILES: CN(C)CCNc1ccc(cn1)-c1c[nH]c2cc(F)ccc12

InChI Key: InChIKey=OZUJWEGFRKWWLN-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339955   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))		BDBM339955
PNG
(N1-(5-(6-fluoro-1H-indol-3- yl)pyridin-2-yl)-N2,N2...)
Show SMILES CN(C)CCNc1ccc(cn1)-c1c[nH]c2cc(F)ccc12
Show InChI InChI=1S/C17H19FN4/c1-22(2)8-7-19-17-6-3-12(10-21-17)15-11-20-16-9-13(18)4-5-14(15)16/h3-6,9-11,20H,7-8H2,1-2H3,(H,19,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 540n/an/an/an/an/an/a



iTeos Therapeutics

US Patent


Assay Description
The compounds of formula I inhibit the enzymatic activity of human TDO2.To measure the TDO2 activity, the procedure described in Dolusic et al. J. Me...

US Patent US9758505 (2017)


BindingDB Entry DOI: 10.7270/Q20V8FW9
More data for this
Ligand-Target Pair