BDBM340036 1-(3-chloro-2,6-difluorophenyl)-3-(3-fluoro- 4-(7-(5-methyl-1H-imidazol-2-yl)-1- oxoisoindolin-4-yl)phenyl)urea::US10604508, Compound 17::US9758508, Compound 17
SMILES: Cc1cnc([nH]1)-c1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2c(F)ccc(Cl)c2F)cc1F
InChI Key: InChIKey=NFOQPZWNHWIPMK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340036 (1-(3-chloro-2,6-difluorophenyl)-3-(3-fluoro- 4-(7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc. US Patent | Assay Description In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi... | US Patent US10604508 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM340036 (1-(3-chloro-2,6-difluorophenyl)-3-(3-fluoro- 4-(7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
CrystalGenomics, Inc. US Patent | Assay Description In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi... | US Patent US9758508 (2017) BindingDB Entry DOI: 10.7270/Q2W37ZDB | |||||||||||
More data for this Ligand-Target Pair |