BDBM34074 benzamide derivative, 13b
SMILES: Cc1csc(Sc2cc(C(=O)Nc3cccc(N)c3)c(N)cc2F)n1
InChI Key: InChIKey=ACFYHPCMPGGQEQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucokinase/Glucokinase regulatory protein (Homo sapiens (Human)) | BDBM34074 (benzamide derivative, 13b) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences | Assay Description The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph... | Bioorg Med Chem 17: 7301-12 (2009) Article DOI: 10.1016/j.bmc.2009.08.045 BindingDB Entry DOI: 10.7270/Q2DF6PK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen Phosphorylase (PYGM) (Oryctolagus cuniculus (rabbit)) | BDBM34074 (benzamide derivative, 13b) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Shanghai Institutes for Biological Sciences | Assay Description The enzymatic inhibition of phosphorylase activity was monitored using microplate reader (Bio-Rad). In brief, GPa activity was measured in the direct... | Bioorg Med Chem 17: 7301-12 (2009) Article DOI: 10.1016/j.bmc.2009.08.045 BindingDB Entry DOI: 10.7270/Q2DF6PK0 | |||||||||||
More data for this Ligand-Target Pair |