BDBM340740 US9763922, Example 266

SMILES: CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccnc(OC)c1)nn2C1CCOCC1

InChI Key: InChIKey=LAOYTUBUOKNSMA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340740   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM340740 (US9763922, Example 266) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccnc(OC)c1)nn2C1CCOCC1 Show InChI InChI=1S/C26H29F3N6O3/c1-30-26(36)34-8-4-22-19(14-34)25(33-35(22)16-5-9-38-10-6-16)32-21-13-18(24(28)29)17(12-20(21)27)15-3-7-31-23(11-15)37-2/h3,7,11-13,16,24H,4-6,8-10,14H2,1-2H3,(H,30,36)(H,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM340740 (US9763922, Example 266) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccnc(OC)c1)nn2C1CCOCC1 Show InChI InChI=1S/C26H29F3N6O3/c1-30-26(36)34-8-4-22-19(14-34)25(33-35(22)16-5-9-38-10-6-16)32-21-13-18(24(28)29)17(12-20(21)27)15-3-7-31-23(11-15)37-2/h3,7,11-13,16,24H,4-6,8-10,14H2,1-2H3,(H,30,36)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair