BDBM340746 US9763922, Example 272

SMILES: CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccc(nc1)C(=O)NC)nn2C1CCOCC1

InChI Key: InChIKey=LJHLXTKMDSJXRZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM340746 (US9763922, Example 272) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccc(nc1)C(=O)NC)nn2C1CCOCC1 Show InChI InChI=1S/C27H30F3N7O3/c1-31-26(38)21-4-3-15(13-33-21)17-11-20(28)22(12-18(17)24(29)30)34-25-19-14-36(27(39)32-2)8-5-23(19)37(35-25)16-6-9-40-10-7-16/h3-4,11-13,16,24H,5-10,14H2,1-2H3,(H,31,38)(H,32,39)(H,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM340746 (US9763922, Example 272) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccc(nc1)C(=O)NC)nn2C1CCOCC1 Show InChI InChI=1S/C27H30F3N7O3/c1-31-26(38)21-4-3-15(13-33-21)17-11-20(28)22(12-18(17)24(29)30)34-25-19-14-36(27(39)32-2)8-5-23(19)37(35-25)16-6-9-40-10-7-16/h3-4,11-13,16,24H,5-10,14H2,1-2H3,(H,31,38)(H,32,39)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair