BDBM340881 3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyrazin-8-amine::US10544104, Compound 8::US9765037, Compound 8

SMILES: CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12

InChI Key: InChIKey=BUZYGKOYMBGUKX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 340881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calmodulin-domain protein kinase 1 (CDPK1) (Toxoplasma gondii)	BDBM340881 (3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyra...) Show SMILES CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H18N4/c1-12(2)19-22-16(17-18(20)21-9-10-23(17)19)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H2,20,21)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1, putative (Cryptosporidium parvum (strain Iowa II))	BDBM340881 (3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyra...) Show SMILES CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H18N4/c1-12(2)19-22-16(17-18(20)21-9-10-23(17)19)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H2,20,21)	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340881 (3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyra...) Show SMILES CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H18N4/c1-12(2)19-22-16(17-18(20)21-9-10-23(17)19)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H2,20,21)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1) (Cryptosporidium parvum)	BDBM340881 (3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyra...) Show SMILES CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H18N4/c1-12(2)19-22-16(17-18(20)21-9-10-23(17)19)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H2,20,21)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair