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SMILES: CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12

InChI Key: InChIKey=DKEXUOIKEUTIAL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 340883   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calcium-dependent protein kinase 1 (Cryptosporidium parvum)	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands (Cryptosporidium parvum (strain Iowa II))	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077GQ
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1, putative (Cryptosporidium parvum (strain Iowa II))	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
cGMP-dependent protein kinase ()	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077GQ
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340883 (1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...) Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12 Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair