null

SMILES: Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12

InChI Key: InChIKey=SHPLGWYLKVEYNP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 340919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calcium-dependent protein kinase 1 (Cryptosporidium parvum)	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of human tyrosine kinases.				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of human tyrosine kinases.				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands (Cryptosporidium parvum (strain Iowa II))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1, putative (Cryptosporidium parvum (strain Iowa II))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
cGMP-dependent protein kinase ()	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340919 (3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...) Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair