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SMILES: CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12

InChI Key: InChIKey=MZPILEJBIWMIFA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 340947   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.9	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calcium-dependent protein kinase 1 (Cryptosporidium parvum)	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...				US Patent US9765037 (2017) BindingDB Entry DOI: 10.7270/Q2B56MVC
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1 (Toxoplasma gondii)	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.9	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands (Cryptosporidium parvum (strain Iowa II))	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair
cGMP-dependent protein kinase ()	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	24.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calmodulin-domain protein kinase 1, putative (Cryptosporidium parvum (strain Iowa II))	BDBM340947 (3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...) Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12 Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US10544104 (2020) BindingDB Entry DOI: 10.7270/Q2D79DSF
					More data for this Ligand-Target Pair