BDBM341024 1-(5-Chloro-4-fluoro-2-{[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-N-(4-hydroxyphenyl)-N-(1-methyl-1H-indol-5-yl)-1H-indole-3-carboxamide hydrochloride::US9765056, Example 78

SMILES: CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1

InChI Key: InChIKey=BXLKUGVPWBWELE-DHUJRADRSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341024   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM341024 (1-(5-Chloro-4-fluoro-2-{[(3S)-3-[(4-methylpiperazi...) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc(F)c(Cl)cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3ccccc23)CC1 Show InChI InChI=1S/C46H42ClFN6O3/c1-49-19-21-51(22-20-49)28-35-23-30-7-3-4-8-32(30)27-52(35)45(56)38-25-41(48)40(47)26-44(38)53-29-39(37-9-5-6-10-43(37)53)46(57)54(33-11-14-36(55)15-12-33)34-13-16-42-31(24-34)17-18-50(42)2/h3-18,24-26,29,35,55H,19-23,27-28H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...				US Patent US9765056 (2017) BindingDB Entry DOI: 10.7270/Q2T72KJF
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