BDBM341126 1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(1H-indol-5-yl)-N-phenyl-1H-indole-3-carboxamide::US9765056, Example 198
SMILES: COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccccc2)c2ccc3[nH]ccc3c2)c2ccccc12
InChI Key: InChIKey=GPYIKLBRTXFTJU-BHVANESWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apoptosis regulator Bcl-2 (Homo sapiens (Human)) | BDBM341126 (1-{4-Hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperaz...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent | Assay Description Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c... | US Patent US9765056 (2017) BindingDB Entry DOI: 10.7270/Q2T72KJF | |||||||||||
More data for this Ligand-Target Pair |