null
SMILES: Nc1nc(N)c(C#N)c(N[C@@H](c2ccccc2)c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)n1
InChI Key: InChIKey=GWMBPACLSXYONO-NRFANRHFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM341173 ((S)-2,4-diamino-6-(((5-chloro-4-oxo-3-phenyl-3,4-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
GILEAD SCIENCES, INC. US Patent | Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks... | US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH | |||||||||||
More data for this Ligand-Target Pair |