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SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCC(N)=O)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=YWYXEDPNCIDLEF-ZDUSSCGKSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341210   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM341210
PNG
((S)-3-(2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)am...)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCC(N)=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H23N9O2/c1-13(29-21-16(12-25)20(27)31-24(28)32-21)22-30-17-9-5-6-14(10-11-18(26)34)19(17)23(35)33(22)15-7-3-2-4-8-15/h2-9,13H,10-11H2,1H3,(H2,26,34)(H5,27,28,29,31,32)/t13-/m0/s1
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MMDB

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US Patent
n/an/a 0.5n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...

US Patent US9765060 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BDH
More data for this
Ligand-Target Pair