BDBM341236 (S)-4-((1-(5-(3-(2-oxa-6-azaspiro[3.4]octan-6-yl)propyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)-2,6-diaminopyrimidine-5-carbonitrile ::US9765060, Compound 63

SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCN3CCC4(COC4)C3)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=ICRKSHNYKMPASN-IBGZPJMESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341236   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM341236 ((S)-4-((1-(5-(3-(2-oxa-6-azaspiro[3.4]octan-6-yl)p...) Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCN3CCC4(COC4)C3)c2c(=O)n1-c1ccccc1 Show InChI InChI=1S/C30H33N9O2/c1-19(34-26-22(15-31)25(32)36-29(33)37-26)27-35-23-11-5-7-20(8-6-13-38-14-12-30(16-38)17-41-18-30)24(23)28(40)39(27)21-9-3-2-4-10-21/h2-5,7,9-11,19H,6,8,12-14,16-18H2,1H3,(H5,32,33,34,36,37)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
GILEAD SCIENCES, INC. US Patent					Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...				US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH
					More data for this Ligand-Target Pair