BDBM341277 6-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-cyclobutylpropanoyl}-amino)imidazo[1,2-a]pyridine-2-carboxylic acid (racemate)::US9765070, Example 5

SMILES: COc1cn(C(CC2CCC2)C(=O)Nc2ccc3nc(cn3c2)C(O)=O)c(=O)cc1-c1cc(Cl)ccc1C#N

InChI Key: InChIKey=QPLOFYKBIFMXBX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 341277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM341277 (6-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COc1cn(C(CC2CCC2)C(=O)Nc2ccc3nc(cn3c2)C(O)=O)c(=O)cc1-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C28H24ClN5O5/c1-39-24-15-34(26(35)11-21(24)20-10-18(29)6-5-17(20)12-30)23(9-16-3-2-4-16)27(36)31-19-7-8-25-32-22(28(37)38)14-33(25)13-19/h5-8,10-11,13-16,23H,2-4,9H2,1H3,(H,31,36)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting final con...				US Patent US9765070 (2017) BindingDB Entry DOI: 10.7270/Q25D8TZT
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM341277 (6-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...) Show SMILES COc1cn(C(CC2CCC2)C(=O)Nc2ccc3nc(cn3c2)C(O)=O)c(=O)cc1-c1cc(Cl)ccc1C#N Show InChI InChI=1S/C28H24ClN5O5/c1-39-24-15-34(26(35)11-21(24)20-10-18(29)6-5-17(20)12-30)23(9-16-3-2-4-16)27(36)31-19-7-8-25-32-22(28(37)38)14-33(25)13-19/h5-8,10-11,13-16,23H,2-4,9H2,1H3,(H,31,36)(H,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Test substances are dissolved in dimethyl sulphoxide and serially diluted in dimethyl sulphoxide (3000 μM to 0.0078 μM; resulting final con...				US Patent US9765070 (2017) BindingDB Entry DOI: 10.7270/Q25D8TZT
					More data for this Ligand-Target Pair