BDBM341471 5-(6-(2-((2-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yl)oxy)acetyl)-2-methyl-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-5-yl)-4-fluoro-N,N-dimethylthiophene-2-carboxamide::US9765092, Example 1.24.6

SMILES: CN(C)C(=O)c1cc(F)c(s1)C1N(CCc2nc3sc(C)nn3c12)C(=O)COc1ccc(nc1Cl)N1CC(F)(F)C1

InChI Key: InChIKey=FTONTNHISIBYLE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM341471 (5-(6-(2-((2-chloro-6-(3,3-difluoroazetidin-1-yl)py...) Show SMILES CN(C)C(=O)c1cc(F)c(s1)C1N(CCc2nc3sc(C)nn3c12)C(=O)COc1ccc(nc1Cl)N1CC(F)(F)C1 Show InChI InChI=1S/C25H23ClF3N7O3S2/c1-12-32-36-19-14(30-24(36)40-12)6-7-35(20(19)21-13(27)8-16(41-21)23(38)33(2)3)18(37)9-39-15-4-5-17(31-22(15)26)34-10-25(28,29)11-34/h4-5,8,20H,6-7,9-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
ACTELION PHARMACEUTICALS LTD US Patent					Assay Description To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...				US Patent US9765092 (2017) BindingDB Entry DOI: 10.7270/Q21N838B
					More data for this Ligand-Target Pair