BDBM341617 1-(5-(3,4-dimethoxyphenyl)-7,8-dihydrothiazolo-[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-(naphthalen-2-yloxy)ethanone::US9765092, Example 6.1.1

SMILES: COc1ccc(cc1OC)C1N(CCc2nc3sccn3c12)C(=O)COc1ccc2ccccc2c1

InChI Key: InChIKey=BQAHNNFKOWIMJO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341617   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM341617 (1-(5-(3,4-dimethoxyphenyl)-7,8-dihydrothiazolo-[2'...) Show SMILES COc1ccc(cc1OC)C1N(CCc2nc3sccn3c12)C(=O)COc1ccc2ccccc2c1 Show InChI InChI=1S/C28H25N3O4S/c1-33-23-10-8-20(16-24(23)34-2)26-27-22(29-28-31(27)13-14-36-28)11-12-30(26)25(32)17-35-21-9-7-18-5-3-4-6-19(18)15-21/h3-10,13-16,26H,11-12,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ACTELION PHARMACEUTICALS LTD US Patent					Assay Description To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...				US Patent US9765092 (2017) BindingDB Entry DOI: 10.7270/Q21N838B
					More data for this Ligand-Target Pair