BDBM341629 1-(5-(2-fluoro-4-methoxyphenyl)-7,8-dihydrothiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-(isoquinolin-7-yloxy)ethanone::US9765092, Example 6.3.3

SMILES: COc1ccc(C2N(CCc3nc4sccn4c23)C(=O)COc2ccc3ccncc3c2)c(F)c1

InChI Key: InChIKey=BPWZZBCDTGALMF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM341629 (1-(5-(2-fluoro-4-methoxyphenyl)-7,8-dihydrothiazol...) Show SMILES COc1ccc(C2N(CCc3nc4sccn4c23)C(=O)COc2ccc3ccncc3c2)c(F)c1 Show InChI InChI=1S/C26H21FN4O3S/c1-33-18-4-5-20(21(27)13-18)24-25-22(29-26-31(25)10-11-35-26)7-9-30(24)23(32)15-34-19-3-2-16-6-8-28-14-17(16)12-19/h2-6,8,10-14,24H,7,9,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ACTELION PHARMACEUTICALS LTD US Patent					Assay Description To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...				US Patent US9765092 (2017) BindingDB Entry DOI: 10.7270/Q21N838B
					More data for this Ligand-Target Pair