BDBM341644 2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4-cyclopropyl-2-fluorophenyl)-7,8-dihydrothiazolo-[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone::US9765092, Example 6.6.1
SMILES: Fc1cc(ccc1C1N(CCc2nc3sccn3c12)C(=O)COc1ccc(nc1Cl)N1CCOCC1)C1CC1
InChI Key: InChIKey=XCCFCSLAQCGUKN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human)) | BDBM341644 (2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ACTELION PHARMACEUTICALS LTD US Patent | Assay Description To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu... | US Patent US9765092 (2017) BindingDB Entry DOI: 10.7270/Q21N838B | |||||||||||
More data for this Ligand-Target Pair |