BDBM341654 2-(4-chloro-2-methylphenoxy)-1-(5-(2-fluoro-4-methyl-phenyl)-7,8-dihydrothiazolo[2',3':2,3]imidazo[4,5-c]-pyridin-6(5H)-yl)ethanone::US9765092, Example 6.10.1

SMILES: Cc1ccc(C2N(CCc3nc4sccn4c23)C(=O)COc2ccc(Cl)cc2C)c(F)c1

InChI Key: InChIKey=VUFITPLVHLCSDU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM341654 (2-(4-chloro-2-methylphenoxy)-1-(5-(2-fluoro-4-meth...) Show SMILES Cc1ccc(C2N(CCc3nc4sccn4c23)C(=O)COc2ccc(Cl)cc2C)c(F)c1 Show InChI InChI=1S/C24H21ClFN3O2S/c1-14-3-5-17(18(26)11-14)22-23-19(27-24-29(23)9-10-32-24)7-8-28(22)21(30)13-31-20-6-4-16(25)12-15(20)2/h3-6,9-12,22H,7-8,13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
ACTELION PHARMACEUTICALS LTD US Patent					Assay Description To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...				US Patent US9765092 (2017) BindingDB Entry DOI: 10.7270/Q21N838B
					More data for this Ligand-Target Pair