null

SMILES: Cc1nc([nH]c1-c1cccc(OC(F)(F)F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1

InChI Key: InChIKey=MIMAOXCZKVQPAQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342169   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342169 (6-(4-fluorophenyl)-4-[4-[4-methyl-5-[3- (trifluoro...) Show SMILES Cc1nc([nH]c1-c1cccc(OC(F)(F)F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H24F4N6O/c1-16-24(19-3-2-4-21(13-19)39-28(30,31)32)37-25(35-16)18-9-11-38(12-10-18)27-22-14-23(36-26(22)33-15-34-27)17-5-7-20(29)8-6-17/h2-8,13-15,18H,9-12H2,1H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342169 (6-(4-fluorophenyl)-4-[4-[4-methyl-5-[3- (trifluoro...) Show SMILES Cc1nc([nH]c1-c1cccc(OC(F)(F)F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H24F4N6O/c1-16-24(19-3-2-4-21(13-19)39-28(30,31)32)37-25(35-16)18-9-11-38(12-10-18)27-22-14-23(36-26(22)33-15-34-27)17-5-7-20(29)8-6-17/h2-8,13-15,18H,9-12H2,1H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair