null

SMILES: COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N

InChI Key: InChIKey=SGLCEFGMXUNWFV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342221 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-19-15-23(9-10-26(19)39-4)27-20(2)35-30(37-27)31(3)11-13-38(14-12-31)29-24-16-25(36-28(24)33-18-34-29)22-7-5-21(17-32)6-8-22/h5-10,15-16,18H,11-14H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342221 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-19-15-23(9-10-26(19)39-4)27-20(2)35-30(37-27)31(3)11-13-38(14-12-31)29-24-16-25(36-28(24)33-18-34-29)22-7-5-21(17-32)6-8-22/h5-10,15-16,18H,11-14H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair