null

SMILES: COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F

InChI Key: InChIKey=QSAQUQUUXPPWSH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342322   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342322 (6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- [5-(4-met...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C28H30F2N8O/c1-16-11-18(5-6-22(16)39-4)23-17(2)34-26(36-23)28(3)7-9-37(10-8-28)25-20-12-21(35-24(20)31-15-32-25)19-13-33-38(14-19)27(29)30/h5-6,11-15,27H,7-10H2,1-4H3,(H,34,36)(H,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342322 (6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- [5-(4-met...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C28H30F2N8O/c1-16-11-18(5-6-22(16)39-4)23-17(2)34-26(36-23)28(3)7-9-37(10-8-28)25-20-12-21(35-24(20)31-15-32-25)19-13-33-38(14-19)27(29)30/h5-6,11-15,27H,7-10H2,1-4H3,(H,34,36)(H,31,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair