null

SMILES: COc1ncc(cc1F)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N

InChI Key: InChIKey=UYZYUZCLXCINDL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342341   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342341 (4-[4-[4-[5-(5-fluoro-6-methoxy-3- pyridyl)-4-methy...) Show SMILES COc1ncc(cc1F)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H25FN8O/c1-16-24(20-11-22(29)28(38-2)31-14-20)36-25(34-16)19-7-9-37(10-8-19)27-21-12-23(35-26(21)32-15-33-27)18-5-3-17(13-30)4-6-18/h3-6,11-12,14-15,19H,7-10H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342341 (4-[4-[4-[5-(5-fluoro-6-methoxy-3- pyridyl)-4-methy...) Show SMILES COc1ncc(cc1F)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H25FN8O/c1-16-24(20-11-22(29)28(38-2)31-14-20)36-25(34-16)19-7-9-37(10-8-19)27-21-12-23(35-26(21)32-15-33-27)18-5-3-17(13-30)4-6-18/h3-6,11-12,14-15,19H,7-10H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair