null

SMILES: Cc1nc([nH]c1-c1ccc(cc1)C(F)F)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(NS(C)(=O)=O)cc1

InChI Key: InChIKey=QUDFCXBYLIJSQQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342415 (N-[4-[4-[4-[5-[4- (difluoromethyl)phenyl]-4-methyl...) Show SMILES Cc1nc([nH]c1-c1ccc(cc1)C(F)F)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C30H31F2N7O2S/c1-18-25(20-4-6-21(7-5-20)26(31)32)37-29(35-18)30(2)12-14-39(15-13-30)28-23-16-24(36-27(23)33-17-34-28)19-8-10-22(11-9-19)38-42(3,40)41/h4-11,16-17,26,38H,12-15H2,1-3H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342415 (N-[4-[4-[4-[5-[4- (difluoromethyl)phenyl]-4-methyl...) Show SMILES Cc1nc([nH]c1-c1ccc(cc1)C(F)F)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C30H31F2N7O2S/c1-18-25(20-4-6-21(7-5-20)26(31)32)37-29(35-18)30(2)12-14-39(15-13-30)28-23-16-24(36-27(23)33-17-34-28)19-8-10-22(11-9-19)38-42(3,40)41/h4-11,16-17,26,38H,12-15H2,1-3H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair