BDBM342419 5-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol-2-yl]-4-methyl-1- piperidyl]-7H-pyrrolo[2,3-d]pyrimidin- 6-yl]pyridine-2-carbonitrile::US9771369, Compound P-3256
SMILES: COc1cccc(c1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(nc1)C#N
InChI Key: InChIKey=SIYHNIKBLVVBGW-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human)) | BDBM342419 (5-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon Inc. US Patent | Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ... | US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM342419 (5-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon Inc. US Patent | Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,... | US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q | |||||||||||
More data for this Ligand-Target Pair |