BDBM342447 N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)-yl]- 1,3-thiazol-4-yl}-5- (difluoromethoxy)-3-methyl pyrazine-2-carboxamide::US9771379, Example 22
SMILES: Cc1nc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12CO[C@H](C[C@H]1COC(N)=N2)C(F)(F)F
InChI Key: InChIKey=KZSWBENUZHVEIJ-BTKFHORUSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM342447 (N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. US Patent | Assay Description The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ... | US Patent US9771379 (2017) BindingDB Entry DOI: 10.7270/Q2R78HC1 | |||||||||||
More data for this Ligand-Target Pair |