null

SMILES: Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F

InChI Key: InChIKey=PLXPCRHHULAZDG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342603   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM342603 (N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6...) Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F Show InChI InChI=1S/C22H20F2N2O4S/c1-12-21-15(4-3-5-18(21)27)22(25-12)16-11-14(26-31(2,28)29)7-9-19(16)30-20-8-6-13(23)10-17(20)24/h6-11,25-26H,3-5H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description Compound dilution series were prepared in DMSO via a 3-fold serial dilution from 2.5 mM to 42 nM. Compounds were then diluted 6:100 in assay buffer (...				US Patent US9776990 (2017) BindingDB Entry DOI: 10.7270/Q2ZS2ZPJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM342603 (N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6...) Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F Show InChI InChI=1S/C22H20F2N2O4S/c1-12-21-15(4-3-5-18(21)27)22(25-12)16-11-14(26-31(2,28)29)7-9-19(16)30-20-8-6-13(23)10-17(20)24/h6-11,25-26H,3-5H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent									US Patent US9776990 (2017) BindingDB Entry DOI: 10.7270/Q2ZS2ZPJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM342603 (N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6...) Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F Show InChI InChI=1S/C22H20F2N2O4S/c1-12-21-15(4-3-5-18(21)27)22(25-12)16-11-14(26-31(2,28)29)7-9-19(16)30-20-8-6-13(23)10-17(20)24/h6-11,25-26H,3-5H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	97	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA. Curated by ChEMBL					Assay Description Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assay				Bioorg Med Chem Lett 27: 2225-2233 (2017) Article DOI: 10.1016/j.bmcl.2017.02.057 BindingDB Entry DOI: 10.7270/Q20P12FJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM342603 (N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6...) Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccc(F)cc1F Show InChI InChI=1S/C22H20F2N2O4S/c1-12-21-15(4-3-5-18(21)27)22(25-12)16-11-14(26-31(2,28)29)7-9-19(16)30-20-8-6-13(23)10-17(20)24/h6-11,25-26H,3-5H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA. Curated by ChEMBL					Assay Description Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assay				Bioorg Med Chem Lett 27: 2225-2233 (2017) Article DOI: 10.1016/j.bmcl.2017.02.057 BindingDB Entry DOI: 10.7270/Q20P12FJ
					More data for this Ligand-Target Pair