BDBM3433 1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 15::CHEMBL57323::PD089828 analog 15
SMILES: Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
InChI Key: InChIKey=GQMZTFFTTCUZAW-UHFFFAOYSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 44: 1915-26 (2001) Article DOI: 10.1021/jm0004291 BindingDB Entry DOI: 10.7270/Q29K48DG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 44: 1915-26 (2001) Article DOI: 10.1021/jm0004291 BindingDB Entry DOI: 10.7270/Q29K48DG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 44: 1915-26 (2001) Article DOI: 10.1021/jm0004291 BindingDB Entry DOI: 10.7270/Q29K48DG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Parke-Davis Pharmaceutical Research | Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N... | Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description Inhibitory activity against platelet-derived growth factor receptor | Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs... | Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research Curated by ChEMBL | Assay Description Inhibition of insulin receptor (InsR) tyrosine kinase | J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research Curated by ChEMBL | Assay Description Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinase | J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research Curated by ChEMBL | Assay Description Inhibition of C-src tyrosine kinase | J Med Chem 40: 2296-303 (1997) Article DOI: 10.1021/jm970367n BindingDB Entry DOI: 10.7270/Q2Z31XRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM3433 (1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N... | Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2 | |||||||||||
More data for this Ligand-Target Pair |