BDBM343939 US9777008, Compound 233

SMILES: OC(CNc1cc(ccn1)-c1ncc2ccn(CC(=O)N3CCCC3)c2n1)CN1CCc2ccccc2C1

InChI Key: InChIKey=YYDGPHUNDKHTFB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343939   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343939 (US9777008, Compound 233) Show SMILES OC(CNc1cc(ccn1)-c1ncc2ccn(CC(=O)N3CCCC3)c2n1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C29H33N7O2/c37-25(19-34-13-8-21-5-1-2-6-24(21)18-34)17-31-26-15-22(7-10-30-26)28-32-16-23-9-14-36(29(23)33-28)20-27(38)35-11-3-4-12-35/h1-2,5-7,9-10,14-16,25,37H,3-4,8,11-13,17-20H2,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair