BDBM343942 US9777008, Compound 236

SMILES: Cn1cc2ccc(cc2n1)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1

InChI Key: InChIKey=MNLYQUHZSMTUEQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343942   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343942 (US9777008, Compound 236) Show SMILES Cn1cc2ccc(cc2n1)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1 Show InChI InChI=1S/C25H27N5O/c1-29-15-22-7-6-19(12-24(22)28-29)20-8-10-26-25(13-20)27-14-23(31)17-30-11-9-18-4-2-3-5-21(18)16-30/h2-8,10,12-13,15,23,31H,9,11,14,16-17H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair