BDBM343958 US9777008, Compound 252

SMILES: CN1CCC(CC1)n1cnc2ccc(cc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1

InChI Key: InChIKey=TWULFRLGHKUVOJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343958   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343958 (US9777008, Compound 252) Show SMILES CN1CCC(CC1)n1cnc2ccc(cc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1 Show InChI InChI=1S/C30H36N6O/c1-34-13-10-26(11-14-34)36-21-33-28-7-6-23(16-29(28)36)24-8-12-31-30(17-24)32-18-27(37)20-35-15-9-22-4-2-3-5-25(22)19-35/h2-8,12,16-17,21,26-27,37H,9-11,13-15,18-20H2,1H3,(H,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair