BDBM343961 US9777008, Compound 255

SMILES: OC(CNc1cc(ccn1)-c1ncc2ccn(C3CCNCC3)c2n1)CN1CCc2ccccc2C1

InChI Key: InChIKey=ICEKRFYVADUYCB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343961 (US9777008, Compound 255) Show SMILES OC(CNc1cc(ccn1)-c1ncc2ccn(C3CCNCC3)c2n1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C28H33N7O/c36-25(19-34-13-8-20-3-1-2-4-23(20)18-34)17-31-26-15-21(5-12-30-26)27-32-16-22-9-14-35(28(22)33-27)24-6-10-29-11-7-24/h1-5,9,12,14-16,24-25,29,36H,6-8,10-11,13,17-19H2,(H,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair