BDBM343971 US9777008, Compound 265

SMILES: OC(CNc1cc(ccn1)-c1ccc2ncn(C3COC3)c2c1)CN1CCc2ccccc2C1

InChI Key: InChIKey=OBPDWHCNFFHMQJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343971   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343971 (US9777008, Compound 265) Show SMILES OC(CNc1cc(ccn1)-c1ccc2ncn(C3COC3)c2c1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C27H29N5O2/c33-24(15-31-10-8-19-3-1-2-4-22(19)14-31)13-29-27-12-21(7-9-28-27)20-5-6-25-26(11-20)32(18-30-25)23-16-34-17-23/h1-7,9,11-12,18,23-24,33H,8,10,13-17H2,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair