BDBM344277 N-[6-(4-acetylpiperazin-1-yl)-2-methoxypyridin-3-yl]-5,5-dimethyl-4-oxo-4,7-dihydro-5H-furo[2,3-c]pyran-3-carboxamide::US9777020, Example 171

SMILES: COc1nc(ccc1NC(=O)c1coc2COC(C)(C)C(=O)c12)N1CCN(CC1)C(C)=O

InChI Key: InChIKey=ZGHNQGBDTVTZFT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344277 (N-[6-(4-acetylpiperazin-1-yl)-2-methoxypyridin-3-y...) Show SMILES COc1nc(ccc1NC(=O)c1coc2COC(C)(C)C(=O)c12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C22H26N4O6/c1-13(27)25-7-9-26(10-8-25)17-6-5-15(21(24-17)30-4)23-20(29)14-11-31-16-12-32-22(2,3)19(28)18(14)16/h5-6,11H,7-10,12H2,1-4H3,(H,23,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent									US Patent US9777020 (2017) BindingDB Entry DOI: 10.7270/Q2T155R7
					More data for this Ligand-Target Pair