BDBM344289 N-{6-(4-acetylpiperazin-1-yl)-2-[(1-oxidothietan-3-yl)oxy]pyridin-3-yl}-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrofuro[3,2-c]pyridine-3-carboxamide::US9777020, Example 183

SMILES: CC(=O)N1CCN(CC1)c1ccc(NC(=O)c2coc3CC(C)(C)NC(=O)c23)c(OC2CS(=O)C2)n1

InChI Key: InChIKey=CZWCJBGSWWLKIH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344289 (N-{6-(4-acetylpiperazin-1-yl)-2-[(1-oxidothietan-3...) Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)c2coc3CC(C)(C)NC(=O)c23)c(OC2CS(=O)C2)n1 Show InChI InChI=1S/C24H29N5O6S/c1-14(30)28-6-8-29(9-7-28)19-5-4-17(23(26-19)35-15-12-36(33)13-15)25-21(31)16-11-34-18-10-24(2,3)27-22(32)20(16)18/h4-5,11,15H,6-10,12-13H2,1-3H3,(H,25,31)(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent									US Patent US9777020 (2017) BindingDB Entry DOI: 10.7270/Q2T155R7
					More data for this Ligand-Target Pair