BDBM345277 2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid 1H NMR (CD3OD 400 MHz) $#948; 1.52 (s, 6H), 4.58 (s, 2H), 5.10 (s, 2H), 6.55 (s, 1H), 7.30-7.41 (m, 3H), 7.42-7.51 (m, 3H), 8.19 (s, 1H), 8.41 (d, 1H).::US10202350, Example 23::US10214492, Example 23

SMILES: CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O

InChI Key: InChIKey=RIHUQGLIJOYTGB-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 345277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monocarboxylate transporter 4 (Homo sapiens (Human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...				US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB
					More data for this Ligand-Target Pair
Monocarboxylate transporter 4 (Homo sapiens (Human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...				US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB
					More data for this Ligand-Target Pair
Monocarboxylate transporter 1 (Homo sapiens (Human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...				US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0
					More data for this Ligand-Target Pair
Monocarboxylate transporter 4 (Homo sapiens (Human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t...				US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0
					More data for this Ligand-Target Pair
Monocarboxylate transporter 4 (Homo sapiens (Human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known...				US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0
					More data for this Ligand-Target Pair
Malignant T-cell-amplified sequence 1 (Homo sapiens (human))	BDBM345277 (2-[[5-(4-Chlorophenyl)-1-(3- pyridylmethyl)pyrazo...) Show SMILES CC(C)(OCc1cc(-c2ccc(Cl)cc2)n(Cc2cccnc2)n1)C(O)=O Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,19(25)26)27-13-17-10-18(15-5-7-16(21)8-6-15)24(23-17)12-14-4-3-9-22-11-14/h3-11H,12-13H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Vettore, LLC US Patent					Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those...				US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB
					More data for this Ligand-Target Pair