BDBM345338 1-cyclobutyl-4-[1-[4-(4-methoxyphenyl)phe-nyl]sulfonyl-4,5-dihydroimidazol-2-yl]piperazine::US10202354, Example 3
SMILES: COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
InChI Key: InChIKey=ONFFYBIIQNAOCG-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM345338 (1-cyclobutyl-4-[1-[4-(4-methoxyphenyl)phe-nyl]sulf...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent | Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th... | US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62 | |||||||||||
More data for this Ligand-Target Pair |