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SMILES: Cn1ccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1

InChI Key: InChIKey=PBCDNKTVKKINRW-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345363   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific demethylase 2B


(Homo sapiens (Human))		BDBM345363
PNG
(1-cyclobutyl-4-[1-[4-(1-methylpyrazol-3-yl)phenyl]...)
Show SMILES Cn1ccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:20|
Show InChI InChI=1S/C21H28N6O2S/c1-24-11-9-20(23-24)17-5-7-19(8-6-17)30(28,29)27-12-10-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-9,11,18H,2-4,10,12-16H2,1H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...

US Patent US10202354 (2019)


BindingDB Entry DOI: 10.7270/Q2VT1V62
More data for this
Ligand-Target Pair