BDBM346045 4-{2-[6-Methyl-2-(4- trifluoromethyl- phenyl)-3H- benzoimidazol-5- ylamino]-thiazol-4- yl}-benzamide::US10202370, Example 072

SMILES: Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1ccc(cc1)C(N)=O)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=FHIUCXQWWOLSHJ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346045   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM346045 (4-{2-[6-Methyl-2-(4- trifluoromethyl- phenyl)-3H- ...) Show SMILES Cc1cc2nc([nH]c2cc1Nc1nc(cs1)-c1ccc(cc1)C(N)=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H18F3N5OS/c1-13-10-19-20(31-23(30-19)16-6-8-17(9-7-16)25(26,27)28)11-18(13)32-24-33-21(12-35-24)14-2-4-15(5-3-14)22(29)34/h2-12H,1H3,(H2,29,34)(H,30,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
AB SCIENCE US Patent					Assay Description Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat N°G8081) was performed on BaF3 Kit WT cell lin...				US Patent US10202370 (2019) BindingDB Entry DOI: 10.7270/Q2Q52RRK
					More data for this Ligand-Target Pair