null
SMILES: CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1ccc(OC)cc1
InChI Key: InChIKey=HFELRNZIXKMMLK-ICSRJNTNSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Mus musculus (Mouse)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Rattus norvegicus (Rat)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Rattus norvegicus (Rat)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 751 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM346172 ((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | US Patent US10202371 (2019) BindingDB Entry DOI: 10.7270/Q2KD2123 | ||||||||||||
More data for this Ligand-Target Pair |