Found 8 hits for monomerid = 346177 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 452 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346177
(US10202371, Example 7)Show SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1nccs1 |r| Show InChI InChI=1S/C21H21F3N8O3S/c1-2-13-15(17-26-3-8-36-17)35-20(33)32(13)14-9-12(28-19(29-14)31-4-6-34-7-5-31)11-10-27-18(25)30-16(11)21(22,23)24/h3,8-10,13,15H,2,4-7H2,1H3,(H2,25,27,30)/t13-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this Ligand-Target Pair | |